PK-Sim

Clinical Pharmacokinetics Simulator

👤 Patient Data

Sex & Height (cm)

Total Body Weight (kg)

Age (years)

Serum Creatinine (mg/dL)

1.0

IBW (Devine): --

CrCl (C-G): --

💊 Drug Parameter

Simulation Mode / Drug

Route of Admin

Volume of Dist. (Vd) [L/kg]

Clearance (Cl) [L/hr/kg]

Absolute Vd: -- L

Absolute Cl: -- L/h

💉 Dosing Regimen

Dose (mg)

Interval (tau) [hrs]

12h

# of Doses

Include Loading Dose (2x)?

Concentration vs. Time Profile

Semilog Plot

Conc.

Therapeutic

Toxic

⏱️ Clinical Sampling Predictor Analytical Formula

Dose Number (n) (High = SS)

Sampling Time Post-Dose (t)

hrs

Predicted Plasma Conc.

-- mg/L

Patient Half-Life (t1/2)

-- h

Elimination Phase

Steady State Peak (C_max,ss)

-- mg/L

---

Steady State Trough (C_min,ss)

-- mg/L

---

Time to Steady State

-- h

5 x t1/2

Calculate required dose to hit target peak/trough based on current Vd/Kel.

1. Targets

Desired Peak (mg/L)

Desired Trough (mg/L)

Fixed Interval (Hrs) [Optional]

2. Patient Params

Kel (hr^-1)

Vd (Liters) [Absolute]

T1/2: -- h

✓ Action Successful

⏱️ Clinical Sampling Predictor Analytical Formula

1. Targets

2. Patient Params

3. Results

Calculated Params

1. Patient Demographics

2. Exact Analytical Pharmacokinetics